research question

I’ve chosen my research question on a topic that both benefits and interests me as I have a parent that has type 2 diabetes mellitus and has lived with it for 30 years. After a recent assignment on diabetes and CKD, I have learnt so much and wanted the opportunity to investigate more. With the shift in modern society from growing our own vegetables, to the convenience of fast food our bodies haven’t evolved to process said food. T2DM is a 21st century disease, everything is being made easier for the population to not have to hunt and gather as our ancestors did. Part of the 21st century epidemic is also curing disease with medication, as opposed to making lifestyle changes for life, so there is no need for pharmacology intervention.

P – Populations living with type 2 Diabetes Mellitus

I – Non – Pharmacological (diet and lifestyle changes) intervention

C – Pharmacological Intervention

O- Disease progression over a lifespan

Research Question: Is disease progression identical in populations with T2DM comparing pharmacological and non-pharmacological interventions?

Type 2 Diabetes Mellitus is an autoimmune disorder. It’s a condition where the body cannot maintain normal blood glucose levels. It includes several disorders that are characterized by either insufficient or no release of insulin by the islet cells of the pancreas. (Craft et. Al. Pge.1098 (2017)) This preventable autoimmune disorder most commonly results from long term poor diet resulting in co-morbidities such as obesity, heart disease, peripheral neuropathy and kidney disease. Indigenous people of Australia are “3 times more likely to have diabetes as their non indigenous counterparts”. ( Symptoms of type 2 diabetes often develop slowly over the course of several years, many people have no symptoms. The risk of T2DM increases as you get older, especially in your 40’s.







The results of the multiple treatment comparison analysis agreed with the direct comparisons and found that lifestyle interventions had the highest probability of being the best choice (87.4%). When broken down into specific types of intervention, diet combined with exercise had the highest probability of being the best choice (33.8%), followed by anti-obesity drugs and lifestyle advice (31.4)” (


In conclusion, maintaining a healthy lifestyle that is a combination of a modified diet and regular and consistent exercise from diagnosis would prevent development of co morbidities and increase quality and quantity of life. This would reduce the need for pharmacology interventions from the onset. “Type 2 diabetes mellitus makes up 95% of all diabetes cases. Overwhelming evidence shows that lifestyle intervention programs promoting healthy diets, physical activity and modest body weight reductions can prevent or delay the onset of type 2 diabetes mellitus”. (












Craft, J., Gordon, C., Huether, S., McCance, K., Brashers, V. & Rote, N. (2017) Understanding Pathophysiology. Elsevier. 3E